When a mysterious cataclysmic event, "the blue flash," causes the population of the earth to shrink in size to six inches tall, suddenly humanity has the tables turned on itself: The very civilization it has created becomes its greatest obstacle to survival. Animals and the environment, which have long suffered under the rule and/or destruction of humans, are now some of their most feared enemies. Amid the confusion and turmoil, two strong teenagers, 18-year-old Mouse and his younger sister Beat, emerge as the most promising leaders, eventually setting out on a quest to discover the secret that could redeem this strange new world.